Picking the lock of coordination cage catalysis
The design principles of metallo-organic assembly reactions have facilitated access to hundreds of coordination cages of varying size and shape. Many of these assemblies possess a well-defined cavity capable of hosting a guest, pictorially mimicking the action of a substrate binding to the active si...
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| Published in | Chemical science (Cambridge) Vol. 14; no. 41; pp. 113 - 11331 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
25.10.2023
The Royal Society of Chemistry |
| Subjects | |
| Online Access | Get full text |
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| Summary: | The design principles of metallo-organic assembly reactions have facilitated access to hundreds of coordination cages of varying size and shape. Many of these assemblies possess a well-defined cavity capable of hosting a guest, pictorially mimicking the action of a substrate binding to the active site of an enzyme. While there are now a growing collection of coordination cages that show highly proficient catalysis, exhibiting both excellent activity and efficient turnover, this number is still small compared to the vast library of metal-organic structures that are known. In this review, we will attempt to unpick and discuss the key features that make an effective coordination cage catalyst, linking structure to activity (and selectivity) using lessons learnt from both experimental and computational analysis of the most notable exemplars. We will also provide an outlook for this area, reasoning why coordination cages have the potential to become the gold-standard in (synthetic) non-covalent catalysis.
We provide an overview of coordination cage catalysis, highlighting how mechanistic understanding can help address the challenges in this area leading to new opportunities in non-covalent reactivity. |
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| Bibliography: | Dr Vicente Martí-Centelles received his PhD with honours in 2012 at the Universitat Jaume I (Spain) under the supervision of Prof. Santiago Luis. He then worked as a post-doctoral researcher in the same group, also spending time with Prof. Paul Beer at the University of Oxford. He then moved to the University of Edinburgh in 2016 to work with Prof. Paul Lusby on catalytic coordination cages. After a Marie Curie IF fellowship at CNRS/University of Bordeaux (2019-20) under the guidance of Dr Nathan McClenaghan, he moved back to Spain, where he is currently a CIDEGENT Distinguished Researcher at the Universitat Politècnica de València (Spain). His research interests include supramolecular chemistry, molecular recognition and sensing, and biological applications of supramolecular systems. Prof. Fernanda Duarte was born in Santiago, Chile. She completed undergraduate and graduate studies at Pontificia Universidad Católica de Chile (PUC), undertaking research in inorganic and computational chemistry with Prof. Bárbara Loeb and Prof. Alejandro Toro-Labbé, respectively. From 2012-2015 she held a postdoctoral position at Uppsala University, working with Prof. Lynn Kamerlin, specialising in biomolecular modelling. In 2015, she moved to the UK with a Royal Society Newton Fellowship at the University of Oxford, followed by a Chancellor's Fellowship in Edinburgh. In 2018 Fernanda returned to Oxford, where she is currently an Associate Professor and Tutorial Fellow at Hertford College. Her research programme focuses on developing computational methods to understand (bio)chemical reactions and guide molecular design. Prof. Paul Lusby carried out his PhD at the University of York (1996-2000), working on enzyme mimics under the supervision of Prof. Paul Walton. From 2000-2016, he worked with Prof. David Leigh at the universities of Warwick and Edinburgh, developing metal template methods for the synthesis of interlocked molecules and molecular machines. In 2006, he was awarded a Royal Society URF, remaining at the University of Edinburgh, where he has subsequently been promoted to Senior Lecturer (2014) and Professor (2022). His research interests lie in the functional properties of supramolecular systems, focusing on the use of coordination cages in catalysis, bio-medicine and magnetism. Dr Tomasz Piskorz was born in Kraków, Poland. He completed his BSc and MSc studies at the University of Warsaw. In 2014, he moved to Delft University of Technology to pursue his PhD under the guidance of Prof. Jan van Esch and Dr Alex de Vries (University of Groningen). His doctoral research focused on computational studies of the self-assembly of monolayer networks and low-molecular-weight gelators. Since 2019, he has been a post-doctoral researcher at Oxford University, working with Prof. Fernanda Duarte on the modelling of self-assembly processes and design of catalytic metallo-organic cages. Dr Rebecca Spicer obtained her MChem degree at the University of St Andrews in 2015. In 2020, she received her PhD in Chemistry from the University of Edinburgh, under the supervision of Prof. Paul Lusby. Her research focused on using cage-guest complexes as catalysts. Currently, she is a postdoctoral researcher in the group of Dr Nicholas Evans at Lancaster University, investigating the synthesis and properties of [1]rotaxanes. She has recently been awarded a Leverhulme Early Career Fellowship, which she will start in early 2024. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 2041-6520 2041-6539 |
| DOI: | 10.1039/d3sc02586a |