Colorimetric assay of l-cysteine based on peroxidase-mimicking DNA-Ag/Pt nanoclusters

This paper reported that the peroxidase-like activity of DNA-Ag/Pt nanoclusters (NCs) can be inhibited significantly by l-cysteine. Based on this finding, a highly sensitive and selective colorimetric detection for l-cysteine was developed with a detection limit (LOD) of 2.0nM and a linear range fro...

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Bibliographic Details
Published inSensors and actuators. B, Chemical Vol. 235; pp. 110 - 116
Main Authors Wu, Liang-Liang, Wang, Li-Ying, Xie, Zheng-Jun, Pan, Na, Peng, Chi-Fang
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2016
Subjects
Actuators
Ag/Pt nanoclusters
Amino acids
Biological properties
Colorimetric detection
Colorimetry
Enzyme mimic
l-Cysteine
Mathematical analysis
Nanostructure
Platinum
Selectivity
l-Cysteine
Ag/Pt nanoclusters
Enzyme mimic
Colorimetric detection
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Summary:This paper reported that the peroxidase-like activity of DNA-Ag/Pt nanoclusters (NCs) can be inhibited significantly by l-cysteine. Based on this finding, a highly sensitive and selective colorimetric detection for l-cysteine was developed with a detection limit (LOD) of 2.0nM and a linear range from 5.0nM to 500nM. This detection for l-cysteine was highly selectivity over other amino acids. The high sensitivity and selectivity of this method facilitated the detection of l-cysteine in biological samples. Moreover, this method developed here was low-cost and simple. These results indicated the excellent analytical application of Ag/Pt NCs as enzyme mimic.
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content type line 23
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2016.05.069