Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands

Herein, we show two new DNA binding small molecules, NCD-RO and NCD-RC , and their ability to bind and selectively assemble ruthenium complexes on G-G mismatch DNA. This study used a naphthyridine carbamate dimer ( NCD ) as an efficient scaffold to assemble metal complexes in a controlled manner on...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 56; no. 39; pp. 5227 - 523
Main Authors Ni, Lu, Yamada, Takeshi, Nakatani, Kazuhiko
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 14.05.2020
Subjects
Base Pair Mismatch
Binding
Carbamates - chemistry
Coordination Complexes - chemistry
Coordination compounds
Deoxyribonucleic acid
Dimerization
Dimers
DNA
DNA - chemistry
Ligands
Molecular Structure
Naphthyridines - chemistry
Ruthenium - chemistry
Ruthenium compounds
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Summary:Herein, we show two new DNA binding small molecules, NCD-RO and NCD-RC , and their ability to bind and selectively assemble ruthenium complexes on G-G mismatch DNA. This study used a naphthyridine carbamate dimer ( NCD ) as an efficient scaffold to assemble metal complexes in a controlled manner on dsDNA. A new molecule containing an NCD moiety and a ruthenium complex was prepared, allowing the assembly of adjoining ruthenium complexes on single dsDNA.
Bibliography:10.1039/d0cc01863e
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc01863e