Information networks in the mammary gland

Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation, differentiation, survival and death of cells. Steroids and simple peptide hormones initiate and carry...

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Bibliographic Details
Published inNature reviews. Molecular cell biology Vol. 6; no. 9; pp. 715 - 725
Main Authors Hennighausen, Lothar, Robinson, Gertraud W
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2005
Subjects
Animals
Animals, Genetically Modified
Breastfeeding & lactation
Cell Lineage
Cells
Connective tissue
Cytokines
Cytokines - metabolism
Epithelial Cells - cytology
Epithelial Cells - physiology
Epithelial Cells - transplantation
Female
Gene Expression Regulation
Genetics
Hormones
Humans
Kinases
Mammary Glands, Animal - anatomy & histology
Mammary Glands, Animal - growth & development
Mammary Glands, Animal - physiology
Mammary Glands, Human - anatomy & histology
Mammary Glands, Human - growth & development
Mammary Glands, Human - physiology
Peptides
Physiology
Pregnancy
Proteins
Puberty
Signal Transduction - physiology
Steroids
Transcription Factors - metabolism
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Summary:Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation, differentiation, survival and death of cells. Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections.
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ISSN:1471-0072
1471-0080
DOI:10.1038/nrm1714