Reproductive and developmental toxicities of zinc supplemented rats
Reproductive and developmental toxicities of zinc supplementation in F 0 rats and F 1 progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl 2) at 0.0, 7.5, 15 and 30 mg/kg-d. ZnCl 2 treatment was associated with deficient energy imbalances, reduced number of live pups/litter,...
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Published in | Reproductive toxicology (Elmsford, N.Y.) Vol. 31; no. 2; pp. 134 - 143 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Inc
01.02.2011
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Reproductive and developmental toxicities of zinc supplementation in F
0 rats and F
1 progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl
2) at 0.0, 7.5, 15 and 30
mg/kg-d. ZnCl
2 treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F
0 females, ZnCl
2 was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F
0 males, ZnCl
2 significantly increased relative liver weight and elevated γ-GGT. In addition, at birth, F
1 males exhibited, a significant (
p
<
0.05) increase in anogenital distance, whereas ZnCl
2 hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl
2 supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0890-6238 1873-1708 |
DOI: | 10.1016/j.reprotox.2010.10.009 |