Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study

• Published in: JMIR research protocols Vol. 8; no. 1; p. e10941
• Main Authors: Hernández-Gallego, Jesús, Llamas-Velasco, Sara, Bermejo-Pareja, Felix, Vega, Saturio, Tapias-Merino, Ester, Rodríguez-Sánchez, Emiliano, Boycheva, Elina, Serrano, José Ignacio, Gil-García, Juan-Francisco, Trincado, Rocio, Sánchez-Rodrigo, José-María Vizcaino, Cacho, Jesús, Contador, Israel, Garcia-Ptacek, Sara, Sierra-Hidalgo, Fernando, Cubo, Esther, Carro, Eva, Villarejo-Galende, Alberto, García García-Patino, Rosalía, Benito-León, Julián
• Format: Journal Article
• Language: English
• Published: Canada JMIR Publications 10.01.2019
• Subjects: Age; Biobanks; Biomarkers; Dementia; Hospitals; Longitudinal studies; Neurological disorders; Observational studies; Original Paper; Parkinson's disease; Population; Population-based studies; Primary care; Quality of life; Questionnaires; Rural areas; Stroke; Tremor (Muscular contraction); Spain; NEDICES; pilot study; population-based study; dementia; essential tremor; longitudinal study; mild cognitive impairment; headache; stroke; Parkinson’s disease; observational study
• ISSN: 1929-0748; 1929-0748
• DOI: 10.2196/10941

The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection).