One-pot synthesis of poly(vinyl alcohol)-based biocompatible block copolymers using a dual initiator for ROP and RAFT polymerization
Biocompatible poly(ε-caprolactone)-b-poly(vinyl alcohol) (PCL-b-PVA), poly(δ-valerolactone)-b-PVA, and poly(trimethylene carbonate)-b-PVA block copolymers were synthesized at 30 °C using a hydroxyl-functionalized xanthate reversible addition-fragmentation chain transfer (RAFT) agent, 2-hydroxyethyl...
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Published in | Polymer (Guilford) Vol. 54; no. 21; pp. 5595 - 5600 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ltd
04.10.2013
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Biocompatible poly(ε-caprolactone)-b-poly(vinyl alcohol) (PCL-b-PVA), poly(δ-valerolactone)-b-PVA, and poly(trimethylene carbonate)-b-PVA block copolymers were synthesized at 30 °C using a hydroxyl-functionalized xanthate reversible addition-fragmentation chain transfer (RAFT) agent, 2-hydroxyethyl 2-(ethoxycarbonothioylthio)propanoate, as a dual initiator for ring-opening polymerization (ROP) and RAFT polymerization in a one-pot procedure. The ROP of ε-caprolactone, δ-valerolactone, and trimethylene carbonate was first performed using diphenyl phosphate as the ROP catalyst followed by the RAFT polymerization of vinyl chloroacetate after quenching the ROP with 4-dimethyamino pyridine. The resulting block copolymers were aminolyzed directly to the PVA-based biocompatible block copolymers by adding hexylamine to the reaction mixture. To the best of our knowledge, this is the most convenient method for synthesizing PVA-based biocompatible block copolymers.
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Bibliography: | http://dx.doi.org/10.1016/j.polymer.2013.07.070 |
ISSN: | 0032-3861 1873-2291 |
DOI: | 10.1016/j.polymer.2013.07.070 |