Severe Liver Damage and Nonallergic Bronchitis with Eosinophilia in a Patient with Follicular Lymphoma Treated with Bendamustine plus Rituximab

A 66-year-old female with follicular lymphoma developed severe liver dysfunction and nonallergic bronchitis after 1 cycle of treatment with bendamustine and rituximab (BR) therapy. Simultaneously, eosinophilia was observed. Further examination revealed negative results for both hepatitis virus-induc...

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Bibliographic Details
Published inCase reports in oncology Vol. 7; no. 2; pp. 497 - 502
Main Authors Jo, Tatsuro, Horio, Kensuke
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 23.07.2014
Karger Publishers
Subjects
Bendamustine
Bronchitis
Eosinophilia
Liver dysfunction
Published: July 2014
Rituximab
Liver dysfunction
Rituximab
Bronchitis
Bendamustine
Eosinophilia
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Summary:A 66-year-old female with follicular lymphoma developed severe liver dysfunction and nonallergic bronchitis after 1 cycle of treatment with bendamustine and rituximab (BR) therapy. Simultaneously, eosinophilia was observed. Further examination revealed negative results for both hepatitis virus-induced liver damage and lymphoma cell invasion into the liver. No bacterial, fungal, or cytomegaloviral infections of the respiratory tract were observed. The patient was treated with steroid pulse therapy followed by prednisolone with complete resolution of her symptoms. This suggests that eosinophilia induced by the treatment with BR may result in liver dysfunction and nonallergic bronchitis.
ISSN:1662-6575
1662-6575
DOI:10.1159/000365566