HIV Type 1 RNA Level as a Clinical Indicator of Renal Pathology in HIV-Infected Patients

• Published in: Clinical infectious diseases Vol. 43; no. 3; pp. 377 - 380
• Main Authors: Estrella, Michelle, Fine, Derek M., Gallant, Joel E., Rahman, M. Hafizur, Nagajothi, Nagapradeep, Racusen, Lorraine C., Scheel, Paul J., Atta, Mohamed G.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.08.2006; University of Chicago Press
• Subjects: Adult; AIDS associated nephropathy; AIDS-Associated Nephropathy - diagnosis; AIDS-Associated Nephropathy - etiology; AIDS-Associated Nephropathy - virology; Biological and medical sciences; Biopsies; Diabetic nephropathies; Female; Highly active antiretroviral therapy; HIV; HIV 1; HIV Infections - complications; HIV-1 - isolation & purification; HIV/AIDS; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Kidney Diseases - diagnosis; Kidney Diseases - pathology; Male; Medical sciences; Middle Aged; Pathology; Retrospective Studies; RNA; RNA, Viral; Vascular diseases; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Immunopathology; HIV-1 virus; Retroviridae; AIDS; Immune deficiency; Lentivirus; Indicator; Kidney; Infection; Virus; Anatomic pathology; Microbiological investigation; Viral disease; Human immunodeficiency virus; Viral load
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/505497

To determine the value of human immunodeficiency virus type 1 (HIV-1) RNA level in distinguishing HIV-associated nephropathy from non–HIV-associated nephropathy renal pathological conditions, we retrospectively compared renal histopathological findings for 86 HIV-infected patients according to HIV-1 RNA levels. We found that HIV-associated nephropathy was unlikely among patients with HIV-1 RNA levels <400 copies/mL. Hypertensive vascular disease surpassed HIV-associated nephropathy as the most common renal pathological finding among the entire cohort. HIV-1 RNA level did not correlate with renal survival.