Tissue engineering strategies for in vivo neovascularisation

Neovascularisation is a promising alternative therapeutic approach to re-establish blood flow in ischaemic tissues of patients suffering from coronary artery or peripheral artery disease. Often, these patients are not suitable candidates for current revascularisation procedures such as coronary angi...

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Bibliographic Details
Published inExpert opinion on biological therapy Vol. 2; no. 8; p. 805
Main Authors Ennett, Alessandra B, Mooney, David J
Format Journal Article
LanguageEnglish
Published England 01.12.2002
Subjects
Animals
Cell Transplantation - physiology
Genetic Therapy
Growth Substances - therapeutic use
Humans
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - genetics
Tissue Engineering - methods
Vascular Diseases - therapy
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Summary:Neovascularisation is a promising alternative therapeutic approach to re-establish blood flow in ischaemic tissues of patients suffering from coronary artery or peripheral artery disease. Often, these patients are not suitable candidates for current revascularisation procedures such as coronary angioplasty or bypass surgery. Several strategies are presently under investigation to induce vascularisation by stimulating the body's natural processes of vasculogenesis, angiogenesis and arteriogenesis. These strategies involve transplantation of various cell types into the ischaemic site and the delivery of recombinant angiogenic agents through direct protein administration or gene transfer. We will examine the basic approaches for these neovacularisation strategies and their therapeutic potential as demonstrated in animal models and human trials to date.
ISSN:1471-2598
DOI:10.1517/14712598.2.8.805