Click and release: bioorthogonal approaches to "on-demand" activation of prodrugs
Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent y...
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| Published in | Chemical Society reviews Vol. 48; no. 4; pp. 177 - 194 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
18.02.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent years, "click and release" approaches have shown great promise in the design of prodrugs because of their bioorthogonality and controlled bond-cleavage, which help ensure prodrug stability during circulation and ready cleavage at the desired site of action. This review highlights recent developments of this research field and discusses issues yet to be addressed.
This review summarizes recent developments in using bioorthogonal chemistry in prodrug design for the delivery of traditional small molecule- and gasotransmitter-based therapeutics. |
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| Bibliography: | Xingyue Ji is a professor at Soochow University. He has been serving as a visiting associate professor at Sichuan University since June 2018. He got both his bachelor's and master's degrees in chemistry from the University of Science and Technology of Beijing in 2006 and 2008, respectively. Thereafter, he moved to Peking Union Medical College Institute of Medicinal Biotechnology, and received his PhD degree in medicinal chemistry in 2011. After that, he took an assistant professor position in the same institution, and he worked as a postdoctoral fellow in Dr Binghe Wang's lab from 2013 to September 2018. Binghe Wang is Regents' Professor of Chemistry and a Georgia Research Alliance Eminent Scholar in Drug Discovery at Georgia State University. He is the Founding Director of the Center for Diagnostics and Therapeutics, the Chief Editor of Medicinal Research Reviews, and the Founding Serial Editor of the "Wiley Series in Drug Discovery and Development." He also serves on the editorial boards of numerous journals. His research interests are in the areas of drug discovery, drug delivery, and new diagnostics. Dr Wang, together with his students and postdocs, has published over 280 papers and edited several books covering the same general areas. Bingchen Yu received his BS degree from Shandong University (2014) and his PhD degree in chemistry from Georgia State University in 2018. He is now working as a postdoctoral fellow in Dr Binghe Wang's lab. Ladie Kimberly De La Cruz is currently pursuing her PhD degree in chemistry under Dr Binghe Wang's supervision at Georgia State University. She obtained her BS degree from the University of the Philippines Los Baños (2011). Zhixiang Pan received his BS degree from Anhui Medical University (2014). He is currently pursuing his PhD degree in chemistry in Dr Binghe Wang's lab. Yueqin Zheng was born in 1988 in Fujian, China. He received his BS degree in materials chemistry from the University of Science and Technology of China (USTC) in 2011 and his PhD degree in medicinal chemistry in 2017 from the Chemistry Department of Georgia State University. Now he is working with Professor Daniel Kohane in Boston Children's Hospital, Harvard Medical School, and Professor Robert S. Langer at the Massachusetts Institute of Technology. His research interests include designing prodrugs for gasotransmitters, developing novel chemical reaction-based drug delivery systems, and local delivery of antibiotics and anesthetics. Bowen Ke received his PhD degree in 2009 from Sichuan University, followed by postdoctoral work at Georgia State University with Dr Binghe Wang. In 2013, he joined the faculty of West China Hospital of Sichuan University as an associate professor. He was awarded the Chinese Pharmaceutical Association (CPA)-Servier Young Investigator Award in Medicinal Chemistry in 2017. His current research interests lie in the general areas of medicinal chemistry and chemical biology, aiming to develop new therapeutic and diagnostic agents. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c8cs00395e |