Synthesis and Bioactive Studies of Complex 8-Hydroxyquinolinato-Bis-(Salicylato) Yttrium (III)

• Published in: Biological trace element research Vol. 147; no. 1-3; pp. 366 - 373
• Main Authors: Li, Xu, Li, Qiang-Guo, Zhang, Hui, Hu, Ji-Lin, Yao, Fei-Hong, Yang, De-Jun, Xiao, Sheng-Xiong, Ye, Li-Juan, Huang, Yi, Guo, Dong-Cai
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.06.2012; Humana Press Inc; Springer Nature B.V
• Subjects: Algorithms; bioactive properties; Biochemistry; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Life Sciences; metabolism; microbial growth; Microbiology; Models, Biological; Molecular Structure; Nutrition; Oncology; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Quinolinic Acid - chemistry; Salicylates - chemistry; Schizosaccharomyces - drug effects; Schizosaccharomyces - growth & development; Schizosaccharomyces pombe; Spectrophotometry, Infrared; Thermodynamics; Thermogravimetry; Trace elements; X-Ray Diffraction; Yeast; Yttrium; Yttrium - chemistry; Thermochemistry; Rare earth; Yttrium; 8-Hydroxyquinolinato-bis-(salicylato) yttrium (III)
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-011-9297-1

This paper reports the synthesis of a new bioactive complex, 8-hydroxyquinolinato-bis-(salicylato) yttrium (III) (HSAY), whose composition and structure were characterized by elemental analysis, IR spectra, thermogravimetric analysis, and X-ray diffraction. The power–time curves of the compounds HSAY, C7H6O3, C9H7NO, and YCl3·6H2O on the growth metabolism of Schizosaccharomyces pombe (S. pombe) were determined at 32.00°C, respectively. The corresponding thermokinetics parameters, which include the microbial growth rate constant (κ), inhibition ratio (I), and half inhibition concentration (IC50), were also derived. The results showed that the generation time was 168.2 min, and all the compounds HSAY, C7H6O3, C9H7NO, and YCl3·6H2O possessed good bioactivities on the growth metabolism of S. pombe, with the values of IC50 being 0.055, 3.57, 0.057, and 1.35 mmol L−1, respectively. The inhibition ability of these compounds above on the growth of the S. pombe has been observed to decrease in the order HSAY>C9H7NO>YCl3·6H2O>C7H6O3.