Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 17; no. 1; pp. 123 - 126
• Main Authors: Kim, Yongsun, Lee, Seung Hoon, Kim, Wan Hee, Kweon, Oh-Kyeong
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 01.03.2016; The Korean Society of Veterinary Science
• Subjects: Acute Disease; Adipose Tissue - cytology; Animals; Case Report; Decompression, Surgical - veterinary; Dog Diseases - therapy; Dogs; Female; Intervertebral Disc Degeneration - therapy; Intervertebral Disc Degeneration - veterinary; Intervertebral Disc Displacement - therapy; Intervertebral Disc Displacement - veterinary; Male; Mesenchymal Stem Cell Transplantation - veterinary; Pain Perception; Treatment Outcome; intervertebral disc disease; adipose derived mesenchymal stem cells; decompression surgery; dog
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2016.17.1.123

Thirty-four dogs with no deep pain perception due to acute thoracolumbar intervertebral disc disease underwent decompression surgery within 1 week of diagnosis. All dogs underwent hemilaminectomy. Adipose derived mesenchymal stem cells (AD-MSCs) were transplanted into the injured spinal cord parenchyma for the AD-MSCs transplant dogs. Long-term outcome was evaluated at the end of the follow-up period (> 6 months). AD-MSCs combination treatment showed better recovery outcomes compared to decompression surgery alone. These results indicate that this stem cell therapy is a potential therapeutic strategy to overcome the limitations of treatment for spinal cord injury in clinical medicine.