[18F]FDG, [11C]PiB, and [18F]AV-1451 PET Imaging of Neurodegeneration in Two Subjects With a History of Repetitive Trauma and Cognitive Decline

• Published in: Frontiers in neurology Vol. 10; p. 831
• Main Authors: Okonkwo, David O., Puffer, Ross C., Minhas, Davneet S., Beers, Sue R., Edelman, Kathryn L., Sharpless, Jane, Laymon, Charles M., Lopresti, Brian J., Benso, Steven, Puccio, Ava M., Pathak, Sudhir, Ikonomovic, Milos D., Mettenburg, Joseph M., Schneider, Walter, Mathis, Chester A., Mountz, James M.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.08.2019
• Subjects: amyloid; CTE; neurodegeneration; Neurology; PET; PiB; TBI; AV-1451; amyloid; CTE; PiB; neurodegeneration; tau; TBI; PET
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2019.00831

Trauma-related neurodegeneration can be difficult to differentiate from multifactorial neurodegenerative syndromes, both clinically and radiographically. We have initiated a protocol for imaging of patients with suspected TBI-related neurodegeneration utilizing volumetric MRI and PET studies, including [ F]FDG indexing cerebral glucose metabolism, [ C]PiB for Aβ deposition, and [ F]AV-1451 for tau deposition. To present results from a neuroimaging protocol for evaluation of TBI-related neurodegeneration in patients with early-onset cognitive decline and a history of TBI. Patients were enrolled in parallel TBI studies and underwent a comprehensive neuropsychological test battery as well as an imaging protocol of volumetric MRI and PET studies. Findings from two patients were compared with two age-matched control subjects without a history of TBI. Both chronic TBI patients demonstrated cognitive deficits consistent with early-onset dementia on neuropsychological testing, and one patient self-reported a diagnosis of probable early-onset AD. Imaging studies demonstrated significant [ F]AV-1451 uptake in the bilateral occipital lobes, substantial [ C]PiB uptake throughout the cortex in both TBI patients, and abnormally decreased [ F]FDG uptake in the posterior temporoparietal areas of the brain. One TBI patient also had subcortical volume loss. Control subjects demonstrated no appreciable [ F]AV-1451 or [ C]PiB uptake, had normal cortical volumes, and had normal cognition profiles on neuropsychological testing. In the two patients presented, the [ C]PiB and [ F]FDG PET scans demonstrate uptake patterns characteristic of AD. [ C]PiB PET scans showed widespread neocortical uptake with less abnormal uptake in the occipital lobes, whereas there was significant [ F]AV-1451 uptake in both occipital lobes.