Adaptive effects of dietary ethanol in the pig: changes in plasma high-density lipoproteins and fecal steroid excretion and mutagenicity

Six young mature male pigs were maintained on a high fat, low fiber “Western” type diet. Substitution of ethanol for sucrose raised plasma total cholesterol, an increase that was solely due to a rise in high-density lipoproteins. Plasma triacylglycerols and apo-B concentrations were unchanged and al...

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Published inThe American journal of clinical nutrition Vol. 36; no. 2; pp. 245 - 250
Main Authors Topping, DL, Weller, RA, Nader, CJ, Calvert, GD, Illman, RJ
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1982
Subjects
Animals
Bile Acids and Salts - metabolism
Body Weight
Diet
Dietary ethanol
Ethanol - pharmacology
fecal bile acids
fecal mutagenicity
Feces - analysis
high-density lipoproteins
Lipids - blood
Lipoproteins, HDL - blood
Male
Mutation
pigs
Steroids - metabolism
Swine
fecal mutagenicity
pigs
fecal bile acids
high-density lipoproteins
Dietary ethanol
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Summary:Six young mature male pigs were maintained on a high fat, low fiber “Western” type diet. Substitution of ethanol for sucrose raised plasma total cholesterol, an increase that was solely due to a rise in high-density lipoproteins. Plasma triacylglycerols and apo-B concentrations were unchanged and although apo-A1rose with ethanol, this was not statistically significant. Ethanol did not alter total fecal steroids but both bile acids and the ratio of bile acids/neutral sterols were increased. In fecal extracts from these animals, mutagenic activity in the Ames bacterial test was also raised. The data are discussed in relation to the relationships between dietary ethanol and coronary heart disease and colorectal cancer.
Bibliography:S30
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ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/36.2.245