Case Report: A Case With Philadelphia Chromosome Positive T-Cell Lymphoblastic Lymphoma and a Review of Literature

Philadelphia chromosome positive (Ph ) in T-lineage acute lymphoproliferative tumors is a rare event in both children and adults. In particular, it has not been reported in T-cell lymphoblastic lymphoma(T-LBL) yet. Here, we describe a patient with Ph T-LBL for both cytogenetic abnormality and fusion...

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Published inFrontiers in oncology Vol. 10; p. 584149
Main Authors Li, Xuewei, Ping, Nana, Wang, Yong, Xu, Xiaoyu, Gao, Lijuan, Zeng, Zhao, Zhang, Ling, Zhang, Zhibo, Xie, Yiyu, Ruan, Changgeng, Wu, Depei, Jin, Zhengming, Chen, Suning
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.01.2021
Subjects
clinical characteristics
managements
Oncology
Philadelphia chromosome
prognosis
T-cell lymphoblastic lymphoma
managements
T-cell lymphoblastic lymphoma
prognosis
clinical characteristics
Philadelphia chromosome
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Summary:Philadelphia chromosome positive (Ph ) in T-lineage acute lymphoproliferative tumors is a rare event in both children and adults. In particular, it has not been reported in T-cell lymphoblastic lymphoma(T-LBL) yet. Here, we describe a patient with Ph T-LBL for both cytogenetic abnormality and fusion transcript. Moreover, we review the published cases of Ph T-cell acute lymphoblastic leukemia (T-ALL) in the literature and summarize their clinical characteristics, management, and prognosis.
Bibliography:Reviewed by: Belinda Pinto Simoes, University of São Paulo, Brazil; Habibe Kurt, Brown University, United States
Edited by: Jose-Maria Ribera, Germans Trias i Pujol Health Science Research Institute (IGTP), Spain
These authors have contributed equally to this work
This article was submitted to Hematologic Malignancies, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.584149