Role of Tissue-Specific Blood Flow and Tissue Recruitment in Insulin-Mediated Glucose Uptake of Human Skeletal Muscle

• Published in: Circulation (New York, N.Y.) Vol. 98; no. 3; pp. 234 - 241
• Main Authors: Bonadonna, Riccardo C., Saccomani, Maria Pia, Del Prato, Stefano, Bonora, Enzo, DeFronzo, Ralph A., Cobelli, Claudio
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 21.07.1998; American Heart Association, Inc
• Subjects: Adult; Biological and medical sciences; Blood Glucose - analysis; Cardiovascular system; Extracellular Space - metabolism; Female; Forearm - blood supply; Glucose - metabolism; Glucose Clamp Technique; Humans; Insulin - blood; Insulin - pharmacology; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Muscle, Skeletal - metabolism; Osmolar Concentration; Regional Blood Flow - drug effects; Human; Exploration; Glucose; Metabolism; Striated muscle; Insulin; Capture; Blood flow; Regulation(control); Blood vessel; Circulatory system; Hemodynamics; Radial artery

Background —Conflicting evidence exists concerning whether insulin-induced vasodilation plays a mechanistic role in the regulation of limb glucose uptake. It can be predicted that if insulin augments blood flow by causing tissue recruitment, this mechanism would enhance limb glucose uptake. Methods...