Novel Replication-Competent Circular DNA Molecules from Healthy Cattle Serum and Milk and Multiple Sclerosis-Affected Human Brain Tissue

Epidemiological data point to the involvement of a cow milk factor in the etiology of multiple sclerosis (MS). Eleven circular DNA molecules closely related to transmissible spongiform encephalopathy (TSE)-associated isolate Sphinx 1.76 were isolated from healthy cattle serum, cow milk, and serum an...

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Published inGenome announcements (Washington, DC) Vol. 2; no. 4
Main Authors Whitley, Corinna, Gunst, Karin, Müller, Hermann, Funk, Mathis, zur Hausen, Harald, de Villiers, Ethel-Michele
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 28.08.2014
Subjects
blood serum
brain
circular DNA
dairy cows
DNA replication
etiology
humans
patients
prion diseases
sclerosis
Viruses
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ISSN2169-8287
2169-8287
DOI10.1128/genomeA.00849-14

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Summary:Epidemiological data point to the involvement of a cow milk factor in the etiology of multiple sclerosis (MS). Eleven circular DNA molecules closely related to transmissible spongiform encephalopathy (TSE)-associated isolate Sphinx 1.76 were isolated from healthy cattle serum, cow milk, and serum and brain tissue from MS patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Present address: Mathis Funk, Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eucaryotes Supérieurs, CNRS UMR 8122, Institut Gustave Roussy, Villejuif, France.
ISSN:2169-8287
2169-8287
DOI:10.1128/genomeA.00849-14