Chromatin Places Metabolism Center Stage

Dynamic changes in histone and transcription factor acetylation modulate gene expression. A study in Science ( Wellen et al., 2009) reports that changes in glucose metabolism alter the availability of acetyl-CoA, the essential cofactor for protein acetylation. These findings reveal a direct connecti...

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Bibliographic Details
Published inCell Vol. 138; no. 1; pp. 18 - 20
Main Author Ladurner, Andreas G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.07.2009
Subjects
Acetyl Coenzyme A - metabolism
Acetylation
Animals
Cell Nucleus - metabolism
Chromatin - metabolism
Cytosol - metabolism
Gene Expression Regulation
Glucose - metabolism
Histones - metabolism
Mitochondria - metabolism
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Summary:Dynamic changes in histone and transcription factor acetylation modulate gene expression. A study in Science ( Wellen et al., 2009) reports that changes in glucose metabolism alter the availability of acetyl-CoA, the essential cofactor for protein acetylation. These findings reveal a direct connection between central metabolism and mammalian gene expression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.06.025