Evolutionary constraints on hub and non-hub proteins in human protein interaction network: Insight from protein connectivity and intrinsic disorder

• Published in: Gene Vol. 434; no. 1; pp. 50 - 55
• Main Authors: Manna, Baisali, Bhattacharya, Tanusree, Kahali, Bratati, Ghosh, Tapash Chandra
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2009
• Subjects: Animals; Evolution, Molecular; Hub proteins; Human; Mice; Multiprotein Complexes - metabolism; Non-hub proteins; Protein Binding; Protein complex; Protein Interaction Mapping; Protein Subunits - metabolism; Proteins - genetics; Proteins - metabolism; Protein–protein interactions network; Structural disorderness; Human; Non-hub proteins; Protein complex; Structural disorderness; Protein–protein interactions network; Hub proteins
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2008.12.013

It has been claimed that proteins with more interacting partners (hubs) are structurally more disordered and have a slow evolutionary rate. Here, in this paper we analyzed the evolutionary rate and structural disorderness of human hub and non-hub proteins present/absent in protein complexes. We observed that both non-hub and hub proteins present in protein complexes, are characterized by high structural disorderness. There exists no significant difference in average evolutionary rate of complex-forming hub and non-hub proteins while we have found a significant difference in the average evolutionary rate between hub and non-hub proteins which are not present in protein complexes. We concluded that higher disorderness in complex forming non-hub proteins facilitates higher number of interactions with a large number of protein subunits. High interaction among protein subunits of complex forming non-hub proteins imposes a selective constraint on their evolutionary rate.