Recent progress of glycopolymer synthesis for biomedical applications

• Published in: Biomaterials science Vol. 7; no. 12; pp. 4848 - 4872
• Main Authors: Pramudya, Irawan, Chung, Hoyong
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.12.2019
• Subjects: Addition polymerization; Adhesives; Bacterial Adhesion - drug effects; Biocompatibility; Biological activity; Biomedical materials; Biopolymers - chemistry; Biopolymers - pharmacology; Biosensors; Carbohydrate Sequence; Carbohydrates; Carbohydrates - chemical synthesis; Carbohydrates - chemistry; Carbohydrates - pharmacology; Control methods; Drug delivery systems; Free radical polymerization; Free radicals; Fuel consumption; Glycopolymers; Humans; Molecular Weight; Molecular weight distribution; Nanoparticles; Organic chemistry; Polymerization; Polymers; Stability
• ISSN: 2047-4830; 2047-4849
• DOI: 10.1039/c9bm01385g

Glycopolymers are an important class of biomaterials which include carbohydrate moieties in their polymer structure. In addition to biological research on the interactions of glycopolymers with lectin-carbonate, glycopolymers have recently been used as a new synthetic biomaterial for direct therapeutic methods, medical adhesives, and biosensors. Thus, a comprehensive understanding of new advances in glycopolymer research is essential for the next level of biomaterial studies. This review article highlights commonly used glycopolymer synthesis methods and biomedical applications thereof. Glycopolymers can be synthesized by modern polymerization methods that can control the molecular weight, molecular weight distribution, chemical functionality, and polymer architecture. The polymerizations include free radical polymerization, atom transfer radical polymerization, reversible addition-fragmentation chain-transfer polymerization, and nitroxide-mediated polymerization. Because the carbohydrate-lectin interactions with glycopolymers are involved in many biological processes, carbohydrates containing glycopolymers are used in (1) fundamental studies to understand the specificity and strength of biological binding, (2) controllable interactions to prevent microorganism adhesion to human cells, (3) large scale bulk adhesives for medical applications, (4) biocompatible therapeutic nanoparticles, (5) direct drug delivery vehicles, and (6) precise quantitative measurement of biosensor materials that can detect physiological signals. Glycopolymers are an important class of biomaterials which include carbohydrate moieties in their polymer structure.