Hydrolysis of vicine and convicine from fababeans by microbial beta-glucosidase enzymes

The toxic glycosides vicine and convicine which are present in fababeans have been implicated in favism, an anaemic disease of humans. Vicine and convicine concentrations are reduced by growth of Lactobacillus plantarum on fababean suspensions. The glycosides are eliminated from the fababean substra...

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Bibliographic Details
Published inJournal of applied bacteriology Vol. 72; no. 6; p. 475
Main Author McKay, A M
Format Journal Article
LanguageEnglish
Published England 01.06.1992
Subjects
Aspergillus oryzae - enzymology
beta-Glucosidase - metabolism
Electrophoresis
Fabaceae - chemistry
Favism - prevention & control
Fusarium - enzymology
Glucosides - adverse effects
Glucosides - metabolism
Humans
Hydrolysis
Lactobacillus - enzymology
Plants, Medicinal
Pyrimidinones - adverse effects
Pyrimidinones - metabolism
Uridine - adverse effects
Uridine - analogs & derivatives
Uridine - metabolism
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Summary:The toxic glycosides vicine and convicine which are present in fababeans have been implicated in favism, an anaemic disease of humans. Vicine and convicine concentrations are reduced by growth of Lactobacillus plantarum on fababean suspensions. The glycosides are eliminated from the fababean substrate by the growth of the filamentous fungus Fusarium graminearum. Incubation of fababean suspension with concentrated culture filtrate of Aspergillus oryzae, induced for extracellular beta-glucosidase production, results in complete degradation of the glycosides. This study suggests a potential use of micro-organisms or microbial enzymes for detoxification of fababeans.
ISSN:0021-8847
DOI:10.1111/j.1365-2672.1992.tb01861.x