NMR studies of chiral recognition by cyclodextrins

Chiral recognition by cyclodextrins is of considerable importance, especially for pharmaceutical industry, in view of the possible side effects of the second enantiometer of chiral drugs. In general, it manifests itself in all NMR parameters (chemical shifts, coupling constants, NOE and ROE effects,...

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Bibliographic Details
Published inChirality (New York, N.Y.) Vol. 16; no. 2; pp. 90 - 105
Main Authors Dodziuk, Helena, Koźmiński, Wiktor, Ejchart, Andrzej
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 2004
Subjects
chiral recognition
complexes
cyclodextrins
Cyclodextrins - chemistry
Cyclodextrins - metabolism
Magnetic Resonance Spectroscopy
NMR
Stereoisomerism
Substrate Specificity
Thermodynamics
Titrimetry
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Summary:Chiral recognition by cyclodextrins is of considerable importance, especially for pharmaceutical industry, in view of the possible side effects of the second enantiometer of chiral drugs. In general, it manifests itself in all NMR parameters (chemical shifts, coupling constants, NOE and ROE effects, and relaxation rates) on one hand. On the other hand, it allows one to determine the thermodynamic parameters characterizing diastereomeric complexes formed by cyclodextrins with enantiomeric guests. After an introduction and a general discussion of NMR manifestations of chiral recognition by cyclodextrin, the existing literature data on this problem will be discussed herein. Chirality 16:90–105, 2004. © 2004 Wiley‐Liss, Inc
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ISSN:0899-0042
1520-636X
DOI:10.1002/chir.10304