Effect of Various Anticoagulant Agents on Large-Volume Leukocytapheresis Using New Cellsorba CS-180S Filter

• Published in: Therapeutic apheresis and dialysis Vol. 15; no. 4; pp. 355 - 359
• Main Authors: Hohtatsu, Katsura, Yamaji, Ken, Yamada, Risa, Oda, Keisuke, Kageyama, Michiaki, Kusaoi, Makio, Onuma, Shin, Kawamoto, Toshio, Sugimoto, Kaoru, Sekiya, Fumio, Kon, Takayuki, Ogasawara, Michihiro, Kempe, Kazuo, Tsuda, Hiroshi, Takasaki, Yoshinari
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.08.2011
• Subjects: Anticoagulant agents; Anticoagulants - administration & dosage; Arthritis, Rheumatoid - therapy; Carbonates - chemistry; Citrates - administration & dosage; Filtration - instrumentation; Guanidines - administration & dosage; Heparin, Low-Molecular-Weight - administration & dosage; Humans; Leukapheresis - instrumentation; Leukapheresis - methods; Leukocytapheresis; Neutrophils - metabolism; New filter; Rheumatoid arthritis; Sodium pyrosulfite; Sulfites - chemistry
• ISSN: 1744-9979; 1744-9987
• DOI: 10.1111/j.1744-9987.2011.00962.x

We conducted a study to evaluate the effect of various anticoagulant agents on large‐volume leukocytapheresis using the new Cellsorba CS‐180S Filter filled with a changed solution of sodium pyrosulfite and sodium carbonate. We conducted the study on a total of 12 cases of rheumatoid arthritis. As the anticoagulant agents we used sodium citrate, nafamostat mesilate and low molecular weight heparin. The new Cellsorba CS‐180S was safely used with the various blood anticoagulant agents. Also, through adjustment of the sodium citrate percentage to the blood flow volume, it is hypothesized that it is possible to increase the neutrophil removal rate.