Usefulness of endoscopic ultrasound-guided sampling using core biopsy needle as a percutaneous biopsy rescue for diagnosis of solid liver mass: Combined histological-cytological analysis

• Published in: Journal of gastroenterology and hepatology Vol. 30; no. 7; pp. 1161 - 1166
• Main Authors: Lee, Yun Nah, Moon, Jong Ho, Kim, Hee Kyung, Choi, Hyun Jong, Choi, Moon Han, Kim, Dong Choon, Lee, Tae Hee, Lee, Tae Hoon, Cha, Sang-Woo, Kim, Sang Gyune, Kim, Young Seok
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.07.2015
• Subjects: Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle - methods; Biopsy, Large-Core Needle - methods; cancer of liver; core needle biopsy; endoscopic ultrasound-guided fine needle aspiration; Endosonography - methods; Female; Histocytological Preparation Techniques - methods; Humans; Image-Guided Biopsy - methods; Liver - pathology; Liver Neoplasms - diagnosis; Liver Neoplasms - pathology; Male; Middle Aged; Sensitivity and Specificity; core needle biopsy; cancer of liver; endoscopic ultrasound-guided fine needle aspiration
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.12922

Background and Study Aims Endoscopic ultrasound (EUS)‐guided fine needle aspiration (EUS‐FNA) is one of the alternative methods for tissue sampling of liver solid mass. However, the diagnostic efficacy using cytology alone was limited. In this study, we evaluate the diagnostic accuracy of EUS‐guided fine needle biopsy (EUS‐FNB) as a percutaneous biopsy rescue for liver solid mass. Patients and Methods The EUS‐FNB using core biopsy needle for liver solid mass was performed prospectively for patients who were failure to acquire a tissue or achieve a diagnosis using percutaneous liver biopsy. The primary outcome was the diagnostic accuracy of EUS‐FNB for malignancy and specific tumor type. The secondary outcomes were the median numbers of passes required to establish a diagnosis, the proportions of patients in whom immunohistochemical (IHC) stain was possible and obtained adequate specimen, and safety of EUS‐FNB. Results Twenty‐one patients (12 women; mean age, 63 years [range, 37–81]) underwent EUS‐FNB for solid liver masses. The median number of needle passes was 2.0 (range, 1–5). On‐site cytology and cytology with Papanicolaou stain showed malignancy in 16 patients (76.2%) and 17 patients (81.0%), respectively. In histology with HE stain, 19 patients (90.5%) were diagnosed malignancy and optimal to IHC stain. The overall diagnostic accuracy for malignancy and specific tumor type were 90.5% and 85.7%, respectively. No complications were seen. Conclusions EUS‐FNB with core biopsy needle for solid liver mass may be helpful in the management of patients who are unable to diagnose using percutaneous liver biopsy.