Salivary gland material from the sand fly Lutzomyia longipalpis has an inhibitory effect on macrophage function in vitro

Previous work from our laboratory demonstrated that the infectivity of the protozoan parasite Leishmania major was enhanced in mice if the infecting inoculum contained salivary gland lysates from the sand fly vector Lutzomyia longipalpis. The present study was designed to address the hypothesis that...

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Bibliographic Details
Published inParasite immunology Vol. 15; no. 8; p. 481
Main Authors Theodos, C M, Titus, R G
Format Journal Article
LanguageEnglish
Published England 01.08.1993
Subjects
Analysis of Variance
Animals
Antigen-Presenting Cells - immunology
Antigens, Protozoan - immunology
Cell Line
Female
Insect Vectors - immunology
Leishmania major - pathogenicity
Leishmaniasis, Cutaneous - immunology
Lymphocyte Activation - immunology
Macrophages - immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred CBA
Psychodidae - immunology
Saliva - immunology
T-Lymphocytes - immunology
Time Factors
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Summary:Previous work from our laboratory demonstrated that the infectivity of the protozoan parasite Leishmania major was enhanced in mice if the infecting inoculum contained salivary gland lysates from the sand fly vector Lutzomyia longipalpis. The present study was designed to address the hypothesis that sand fly salivary gland material may function by inhibiting the host immune response. Results indicated that sand fly saliva inhibited the ability of macrophages to present leishmanial antigens to parasite-specific T cells.
ISSN:0141-9838
1365-3024
DOI:10.1111/j.1365-3024.1993.tb00634.x