The Fisher Variant of Guillain-Barré Syndrome (Fisher Syndrome)

Fisher syndrome (FS) is an acute polyneuropathy typically characterized by the triad of ataxia, areflexia, and ophthalmoplegia, although it may present with 2 or even just 1 of these clinical findings. Similarities between FS and other acute polyneuropathies such as Guillain-Barré syndrome (GBS) and...

Full description

Saved in:
Bibliographic Details
Published inJournal of neuro-ophthalmology Vol. 29; no. 4; pp. 312 - 324
Main Authors Snyder, Lee A, Rismondo, Vivian, Miller, Neil R
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins, Inc 01.12.2009
Subjects
Ataxia - physiopathology
Biomarkers
Disease Progression
Humans
Incidence
Miller Fisher Syndrome - diagnosis
Miller Fisher Syndrome - epidemiology
Miller Fisher Syndrome - physiopathology
Ophthalmoplegia - physiopathology
Online AccessGet full text

Cover

More Information
Summary:Fisher syndrome (FS) is an acute polyneuropathy typically characterized by the triad of ataxia, areflexia, and ophthalmoplegia, although it may present with 2 or even just 1 of these clinical findings. Similarities between FS and other acute polyneuropathies such as Guillain-Barré syndrome (GBS) and Bickerstaff brainstem encephalitis (BBE) suggest that FS is part of a spectrum of autoimmune disorders that may affect the peripheral and/or central nervous system. Anti-GQ1b antibody is present in the serum of more than 85% of patients with FS, but it is not specific to FS. Why some patients develop FS and others develop typical GBS or one of its other variants is still largely unknown.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Feature-1
ISSN:1070-8022
1536-5166
DOI:10.1097/WNO.0b013e3181c2514b