Thyroid Carcinoma in a Japanese Black Cow Living in the Fukushima Daiichi Nuclear Power Plant Accident Contamination Area

• Published in: Bulletin of environmental contamination and toxicology Vol. 114; no. 6; p. 89
• Main Authors: Sasaki, Jun, Sato, Itaru, Okada, Keiji, Deguchi, Yoshitaka, Natsuhori, Masahiro, Murata, Takahisa, Satoh, Hiroshi, Chida, Hiroyuki, Ito, Nobuhiko
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2025; Springer Nature B.V
• Subjects: 2-Methylisoborneol; Animals; Aquatic Pollution; Blood; Cattle; Children & youth; Deer; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Farms; Female; Follicles; Fukushima Nuclear Accident; Japan; Neoplasms, Radiation-Induced - pathology; Neoplasms, Radiation-Induced - veterinary; Nuclear accidents; Nuclear accidents & safety; Nuclear Power Plants; Parenchyma; Pollution; Radiation; Soil Science & Conservation; Thyroglobulin; Thyroid; Thyroid cancer; Thyroid carcinoma; Thyroid gland; Thyroid Gland - pathology; Thyroid Neoplasms - pathology; Thyroid Neoplasms - veterinary; Toxicology; Transcription factors; Tumor cells; Tumors; Veterinary medicine; Waste Water Technology; Water Management; Water Pollution Control; Japan; Cow; Fukushima nuclear accident; Thyroid carcinoma; Japanese black
• ISSN: 0007-4861; 1432-0800; 1432-0800
• DOI: 10.1007/s00128-025-04065-2

The thyroid glands of an 11-year-old castrated cow housed in a region contaminated by the Fukushima Daiichi Nuclear Power Plant accident were collected for histopathological examination. The estimated cumulative external exposure dose was 459 mSv. Macroscopically, the left lobe of the thyroid gland was firm and enlarged, and multilobular cystic structures could be observed on the cut surface. Histologically, the tumor cells were tall, cuboidal to columnar, and formed follicles of variable sizes and shapes. The fibrous capsule was unclear, and the neoplastic invasion of follicular tumor cells was obvious in the adjacent thyroid parenchyma. Immunohistochemically, the tumor cells were positive for thyroglobulin and thyroid transcription factor-1, and the MIB-1 index was 6.2%. Based on these findings, the neoplastic lesion was diagnosed as thyroid carcinoma. This is the first report of thyroid carcinoma in a cow exposed to radiation caused by the Fukushima Daiichi Nuclear Power Plant accident.