About cytokeratin 19 and the drivers of liver regeneration

The postnatal liver is a resting organ with little parenchymal cell turnover. It is estimated that each hepatocyte is replaced three to four times during the lifespan of a mammalian organism. Stem cells around the portal tract have been proposed as the drivers of this slow physiological cell turnove...

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Bibliographic Details
Published inJournal of hepatology Vol. 68; no. 1; pp. 5 - 7
Main Authors Junge, Norman, Sharma, Amar Deep, Ott, Michael
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2018
Elsevier Science Ltd
Subjects
Apoptosis
Cell proliferation
Cytokeratin
Endothelial cells
Hepatocytes
Life span
Liver
Stem cells
Veins & arteries
Wnt protein
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Summary:The postnatal liver is a resting organ with little parenchymal cell turnover. It is estimated that each hepatocyte is replaced three to four times during the lifespan of a mammalian organism. Stem cells around the portal tract have been proposed as the drivers of this slow physiological cell turnover, replacing senescent hepatocytes, which undergo apoptosis close to central veins. A more recent study located physiological hepatocyte regeneration next to the central vein, where Wnt signals from central vein endothelial cells provide a proliferation advantage to adjacent hepatocytes.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2017.10.003