The Role of MicroRNAs in Viral Infection

MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with differen...

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Bibliographic Details
Published inCellular RNA Interference Mechanisms Vol. 102; pp. 101 - 139
Main Authors Roberts, Ashley P.E., Lewis, Andrew P., Jopling, Catherine L.
Format Book Chapter Journal Article
LanguageEnglish
Published United States Elsevier Science & Technology 2011
Subjects
Animals
Base Sequence
Cells - metabolism
Cellular physiology
CLINICAL & INTERNAL MEDICINE
Dicer
Gene Expression Regulation - genetics
HCV
herpesvirus
host-virus interaction
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Molecular biology
Molecular Sequence Data
RNA
RNA, Viral - genetics
RNA, Viral - metabolism
virus
Virus Diseases - genetics
Dicer
RNA
herpesvirus
miRNA
host-virus interaction
HCV
virus
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Summary:MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families expressing their own miRNAs, manipulating host miRNA expression, or showing direct or indirect regulation by host or viral miRNAs. In this chapter we will examine the current evidence for interplay between the miRNA pathway and viral infections in mammals.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISBN:0124157955
9780124157958
ISSN:1877-1173
1878-0814
DOI:10.1016/B978-0-12-415795-8.00002-7