The effects of exercise training on arterial baroreflex sensitivity in neurally mediated syncope patients
Aims The clinical effects of different modalities of treatment for neurally mediated syncope have been studied for years; however, their influences on its pathophysiological mechanisms still have not been determined. This research aimed to observe the effects of physical training, tilt training, and...
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Published in | European heart journal Vol. 28; no. 22; pp. 2749 - 2755 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.11.2007
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
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Summary: | Aims The clinical effects of different modalities of treatment for neurally mediated syncope have been studied for years; however, their influences on its pathophysiological mechanisms still have not been determined. This research aimed to observe the effects of physical training, tilt training, and pharmacological therapy on the arterial baroreflex sensitivity and muscle sympathetic nerve activity in neurally mediated syncope patients. Methods and results Seventy patients with recurrent neurally mediated syncope were included in this study. Patients were divided into the following four groups, depending on the treatment proposed: (i) physical training, (ii) tilt training, (iii) pharmacological therapy, and (iv) control group. All patients underwent an autonomic evaluation with microneurography, when the vagal and sympathetic arterial baroreflex gain were tested, using graded infusions of phenylephrine or sodium nitroprusside, before and 4 months after the interventions. The vagal and sympathetic arterial baroreflex gain significantly increased after a 4-month protocol of physical training. Tilt training, pharmacological therapy, and the control group had no significant change in the arterial baroreceptor responses. Conclusion Physical training improves arterial baroreflex sensitivity in neurally mediated syncope patients and could be applied as a non-pharmacological therapeutic alternative for these patients. |
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Bibliography: | related-article-ID:RA1 ark:/67375/HXZ-CSQNWP64-0 istex:A0C5BC91EB70FAF730A52A0694A8ED9592861AA0 ArticleID:ehm208 Related-article-href:10.1093/eurheartj/ehm431 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0195-668X 1522-9645 |
DOI: | 10.1093/eurheartj/ehm208 |