Iron clad: iron homeostasis and the diagnosis of hereditary iron overload

Iron is an ubiquitous metal of vital importance to the normal physiologic processes of many organisms. Over the last 2 decades, the discovery of mutations in genes leading to hereditary disorders of iron overload, iron deficiency, and iron maldistribution have accelerated our understanding of human...

Full description

Saved in:
Bibliographic Details
Published inHematology Vol. 2014; no. 1; pp. 202 - 209
Main Author Heeney, Matthew M
Format Journal Article
LanguageEnglish
Published United States 05.12.2014
Subjects
Hepcidins - metabolism
Homeostasis
Humans
Iron - metabolism
Iron Overload - diagnosis
Iron Overload - metabolism
Models, Biological
Online AccessGet full text

Cover

More Information
Summary:Iron is an ubiquitous metal of vital importance to the normal physiologic processes of many organisms. Over the last 2 decades, the discovery of mutations in genes leading to hereditary disorders of iron overload, iron deficiency, and iron maldistribution have accelerated our understanding of human iron homeostasis. This chapter provides an updated overview of the human iron cycle, regulation of iron homeostasis, and how perturbations in these homeostatic mechanisms lead to iron overload disease and provides strategies for the diagnosis of hereditary iron overload.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1520-4391
1520-4383
DOI:10.1182/asheducation-2014.1.202