Synthesis and evaluation of new lipomonosaccharide-imprinted polymers as MISPE supports

• Published in: Talanta (Oxford) Vol. 73; no. 2; pp. 340 - 345
• Main Authors: Maury, D., Couderc, F., Garrigues, J.-C., Poinsot, V.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.09.2007; Oxford Elsevier
• Subjects: Amphiphilic monosaccharide; Analytical chemistry; Chemical Sciences; Chemistry; Exact sciences and technology; MISPE; Molecular imprinting; Molecular imprinting; Amphiphilic monosaccharide; MISPE; Ethylene glycol; Solid phase extraction; Molecular structure; Hydrogen; Polymerization; Polymer; Chemical enrichment; Efficiency; Styrene; Methyl methacrylate; Activation analysis
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2007.03.051

Molecular imprinted polymers (MIP) were prepared by the copolymerization of styrene (S) or methyl methacrylate (MMA) and methacrylic acid (MAA) using ethylene glycol dimethacrylate (EGDMA) as the crosslinker with molar ratios of [monomer]/[crosslinker] and [MAA]/[template] of 3:7 (to obtain a rigid structure) and 1:6 (to optimise hydrogen interactions), respectively. The polymerizations occurred in presence of the template molecule (MIP) – GlcNcouma – an amphiphilic monosaccharide. The same materials, non-imprinted polymers (NIP), were also prepared in absence of the template. These MIPs were characterized and used as SPE supports for selective enrichment. The results showed the correlation between retention efficiency and the porogen character of the polymerization solvent.