Adipokines from white adipose tissue in regulation of whole body energy homeostasis

• Published in: Biochimie Vol. 204; pp. 92 - 107
• Main Authors: Sahu, Bijayashree, Bal, Naresh C.
• Format: Journal Article
• Language: English
• Published: France Elsevier B.V 01.01.2023
• Subjects: Adipokine; Adipokines - metabolism; Adipose Tissue - metabolism; Adipose Tissue, White - metabolism; Animals; Batokine; Diabetes Mellitus, Type 2 - metabolism; Energy homeostasis; Energy Metabolism; Homeostasis; Humans; Insulin resistance; Obesity; Obesity - metabolism; WAT; Obesity; Energy homeostasis; Insulin resistance; WAT; Adipokine; Batokine
• ISSN: 0300-9084; 1638-6183
• DOI: 10.1016/j.biochi.2022.09.003

Diseases originating from altered energy homeostasis including obesity, and type 2 diabetes are rapidly increasing worldwide. Research in the last few decades on animal models and humans demonstrates that the white adipose tissue (WAT) is critical for energy balance and more than just an energy storage site. WAT orchestrates the whole-body metabolism through inter-organ crosstalk primarily mediated by cytokines named “Adipokines”. The adipokines influence metabolism and fuel selection of the skeletal muscle and liver thereby fine-tuning the load on WAT itself in physiological conditions like starvation, exercise and cold. In addition, adipokine secretion is influenced by various pathological conditions like obesity, inflammation and diabetes. In this review, we have surveyed the current state of knowledge on important adipokines and their significance in regulating energy balance and metabolic diseases. Furthermore, we have summarized the interplay of pro-inflammatory and anti-inflammatory adipokines in the modulation of pathological conditions. •Adipokines secrete from adipocyte and residing immune cells.•These mediate interorgan cross talk to regulate energy metabolism.•Can be used as prognostic marker for progression of obesity.•Administration of adiponectin and TNF-α can be used to recover insulin resistance.•Vaspin and Cardiotropin are evident to improve nutrient homeostasis in obesity.