Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had large...

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Bibliographic Details
Published inNeurology Vol. 53; no. 9; p. 2176
Main Authors McCarron, M O, Hoffmann, K L, DeLong, D M, Gray, L, Saunders, A M, Alberts, M J
Format Journal Article
LanguageEnglish
Published United States 10.12.1999
Subjects
Aged
Apolipoprotein E4
Apolipoproteins E - genetics
Brain Edema - genetics
Brain Edema - mortality
Cerebral Hemorrhage - genetics
Cerebral Hemorrhage - mortality
Female
Gene Frequency - genetics
Genetic Carrier Screening
Genotype
Hematoma - genetics
Hematoma - mortality
Humans
Male
Middle Aged
Prognosis
Survival Rate
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Summary:We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p<0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p<0.01), but these were not associated with epsilon4 after adjusting for race, age, and type of hemorrhage.
ISSN:0028-3878
DOI:10.1212/wnl.53.9.2176