A rationale for dietary intervention in postmenopausal breast cancer patients: an update

• Published in: Nutrition and cancer Vol. 19; no. 1; p. 1
• Main Authors: Cohen, L.A. (American Health Foundation, Valhalla, NY), Rose, D.P, Wynder, E.L
• Format: Journal Article
• Language: English
• Published: United States 1993
• Subjects: ABSORCION DE SUBSTANCIAS NUTRITIVAS; ABSORPTION DE SUBSTANCES NUTRITIVES; Aged; ANIMAL DE LABORATOIRE; ANIMALES DE LABORATORIO; Animals; Breast Neoplasms - diet therapy; Breast Neoplasms - prevention & control; Clinical Trials as Topic; CORPS GRAS; DIETA; Dietary Fats - administration & dosage; ENCUESTAS SANITARIAS; ENFERMEDADES GLANDULAS MAMARIAS; ENQUETE PATHOLOGIQUE; EPIDEMIA; EPIDEMIE; Estrogens - metabolism; ESTUDIOS DE FACTIBILIDAD; ETUDE DE FAISABILITE; Feasibility Studies; Female; FEMME; GRASAS; Humans; Lung Neoplasms - secondary; Lymphatic Metastasis; MALADIE DES GLANDES MAMMAIRES; Mammary Neoplasms, Experimental - diet therapy; Menopause; Mice; Middle Aged; MODELE; MODELOS; MUJERES; NEOPLASMAS; NEOPLASME; NUTRICION HUMANA; NUTRITION HUMAINE; Rats; REGIME ALIMENTAIRE; RIESGO; Risk Factors; RISQUE
• ISSN: 0163-5581; 1532-7914
• DOI: 10.1080/01635589309514231

In 1982, we proposed a large-scale randomized prospective trial to test the hypothesis that decreasing dietary fat intake from 38% to 20% of total calories would increase the disease-free interval and/or five-year survival rate for postmenopausal breast cancer patients. We now review new evidence from epidemiological studies, laboratory animal model studies, and preliminary feasibility trials that has accumulated over the past decade, in support of such a trial, and suggest that a more appropriate dietary goal is a reduction in fat intake to 15% of total calories