COVID-19 and peripheral arterial complications in people with diabetes and hypertension: A systematic review

• Published in: Diabetes & metabolic syndrome clinical research & reviews Vol. 15; no. 5; p. 102204
• Main Authors: Rastogi, Ashu, Dogra, Himika, Jude, Edward B.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2021; Diabetes India. Published by Elsevier Ltd
• Subjects: COVID-19; Diabetes; Gangrene; Heparin; Peripheral arterial disease; Review; SARS-CoV2; COVID-19; Gangrene; Peripheral arterial disease; SARS-CoV2; Diabetes; Heparin
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2021.102204

Identify the prevalence, risk factors and outcomes of lower extremity ischemic complications. A systematic review was conducted by searching PubMed and SCOPUS databases for SARS-CoV-2, COVID-19 and peripheral arterial complications. Overall 476 articles were retrieved and 31 articles describing 133 patients were included. The mean age was 65.4 years. Pain and gangrene were the most common presentation. Hypertension (51.3%), diabetes (31.9%) and hypercholesterolemia (17.6%) were associated co-morbidities. Overall, 30.1% of patients died and amputation was required in 11.8% patients. COVID-19 patients with diabetes or hypertension are susceptible for lower limb complications and require therapeutic anti-coagulation. •COVID-19 is pro-thrombotic inflammatory state, but peripheral ischemic complications are less often reported.•Almost two-third patients with COVID-19 and peripheral ischemic complications have background hypertension or diabetes•One-third patients with COVID-19 and ischemic complications die and one in ten require amputation•Early therapeutic anti-coagulation should be considered in COVD-19 patients with hypertension or diabetes