Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst...
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| Published in | RSC advances Vol. 11; no. 46; pp. 298 - 2911 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
23.08.2021
The Royal Society of Chemistry |
| Subjects | |
| Online Access | Get full text |
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| Summary: | Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst systemic and phototherapy treatments for moderate to severe psoriasis. However, current therapeutic approaches have a wider extent to treat moderate to severe type of psoriasis especially since the emergence of diverse biologic agents. In the meantime, topical delivery of conventional treatments has prompted many unsatisfactory effects to penetrate through the skin (stratum corneum). By understanding the physiology of stratum corneum barrier functions, scientists have developed different types of lipid-based nanoparticles like solid lipid nanoparticles, nanostructured lipid carriers, nanovesicles, and nanoemulsions. These novel drug delivery systems help the poorly solubilised active pharmaceutical ingredient reaches the targeted site seamlessly because of the bioavailability feature of the nanosized molecules. Lipid-based nanoparticles for psoriasis treatments create a paradigm for topical drug delivery due to their lipids' amphiphilic feature to efficiently encapsulate both lipophilic and hydrophilic drugs. This review highlights different types of lipid-based nanoparticles and their recent works of nano formulated psoriasis treatments. The encapsulation of psoriasis drugs through lipid nanocarriers unfold numerous research opportunities in pharmaceutical applications but also draw challenges for the future development of nano drugs.
Lipid-based nanoparticles are lipidic nanocarriers that can encapsulate different antipsoriatic agents for topical uses, which enhance the alleviation process compared to conventional topical agents (without nanocarriers). |
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| Bibliography: | Norazlinaliza Salim received her PhD (2013) in Oleochemistry from the Universiti Putra Malaysia and went for a research attachment at the IQAC-CSIC, Barcelona, Spain (2010). In 2014, she was a post-doctoral research fellow at Centre for Fundamental and Frontier Sciences in Nano-structure Self-Assembly, Universiti Malaya and thereafter, was appointed as a senior lecturer at the Centre of Foundation Studies for Agricultural Science, Universiti Putra Malaysia. Her research interest is focussed on nanodelivery systems such as nanoemulsion, niosome, etc. for cosmeceutical and pharmaceutical applications. She has published over 25 papers in peer-reviewed indexed journals, one book chapter and five patents. Ummu Umaimah Mohd Nordin received her BSc in Chemistry (Forensic Analysis) from Universiti Teknologi MARA, Shah Alam, Malaysia in 2016. She is currently a Graduate Research Assistant (GRA) while pursuing her master's degree in chemistry under the supervision of Dr Noraini Ahmad and Dr Norazlinaliza Salim at the Department of Chemistry, Faculty of Science, Universiti Malaya. Her current research interests focus on colloid chemistry and nanotechnology. Noraini Ahmad received her PhD (2012) in Physical Chemistry from the Universiti Malaya. She went for a research attachment at the IQAC-CSIC, Barcelona, Spain in 2010 and 2011 funded by InForm Project, EU-FP7 and Ministry of Higher Education Malaysia, respectively. Presently, Noraini is an Associate Professor at the Department of Chemistry, Faculty of Science and Fellow of UM Community and Sustainability Centre (UMCares). Her research interests focus on colloidal chemistry, liquid crystals, and formulation of nanocarrier systems for cosmeceutical, pharmaceutical and nutraceutical applications. She has been awarded with several research grants and won numerous awards locally and internationally. Nor Saadah Mohd Yusof obtained her PhD from the University of Melbourne in 2015. Presently, she is a senior lecturer at the Department of Chemistry, Universiti Malaya. Her research focuses on the micelle structures in the presence of various additives; and their transitional quantification using kinetics techniques. She is also working on sonochemistry and the effect of ultrasound on the micelle structures. Other than that, she also works on the use of ultrasound on other subjects such as to synthesize gold nanoparticles, on natural rubber, sonoencapsulation, sonoextraction, sonopolymerization and sonodegradation such as on food wastes and organic pollutants. |
| ISSN: | 2046-2069 2046-2069 |
| DOI: | 10.1039/d1ra06087b |