Predicting organ carotenoids levels from analysis of plasma could lead to errors: A study in cynomolgus monkeys

• Published in: Nutrition research (New York, N.Y.) Vol. 61; pp. 95 - 101
• Main Authors: Nishino, Azusa, Ichihara, Takashi, Sugimoto, Kazuhisa, Kuriki, Takashi, Yasui, Hiroyuki, Maoka, Takashi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Carotenoid; Monkey study; Tissue accumulation; Xanthophyll; β-Cryptoxanthin; β-Cryptoxanthin; Monkey study; Tissue accumulation; Xanthophyll; Carotenoid
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/j.nutres.2018.10.001

Carotenoids are phytochemicals with strong antioxidant activity against reactive oxygen species that are widely distributed in fruits and vegetables. The beneficial effects of carotenoids on human health have attracted considerable attention. The plasma carotenoid profile in humans is generally recognized to reflect the dietary carotenoid composition. Although carotenoid profile in plasma is believed to correlate well with that in other tissues, the data for tissue accumulation of carotenoids in humans is very limited and poorly understood. In order to test the hypothesis that blood carotenoids reflect tissue accumulation of dietary carotenoids, the cynomolgus monkey was used as a model to determine it's suitable for extrapolation of data on tissue accumulation of carotenoids to humans. Herein, plasma carotenoids were measured in cynomolgus monkeys given a dietary mixture of carotenoids. The findings indicate that cynomolgus monkeys and humans are similar with regard to preferential accumulation of β-cryptoxanthin in the blood and brain. These results suggested that cynomolgus monkeys could be used to collect data on tissue accumulation of carotenoids for extrapolation to humans. The tissue accumulation of carotenoids in other tissues of cynomolgus monkeys that have not yet been evaluated in humans were also investigated, revealing marked differences in carotenoid levels and composition among plasma and various monkey tissues. These results suggest that accumulation of carotenoids in plasma does not reflect necessarily that in tissues, so that predicting the tissue accumulation of carotenoids from plasma carotenoid levels and profiles alone could lead to errors.