Blue light photoredox-catalysed acetalation of alkynyl bromides

Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) sm...

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Bibliographic Details
Published inRSC advances Vol. 9; no. 62; pp. 36213 - 36216
Main Authors Lyu, Xue-Li, Huang, Shi-Sheng, Song, Hong-Jian, Liu, Yu-Xiu, Wang, Qing-Min
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 06.11.2019
The Royal Society of Chemistry
Subjects
Aldehydes
Bromides
Chemistry
Substrates
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Summary:Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) smoothly gave the corresponding acetalation products. This mild protocol has potential utility for the synthesis of aldehydes by further protonization. Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products.
Bibliography:10.1039/c9ra06596b
Electronic supplementary information (ESI) available. See DOI
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ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra06596b