FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N -methyladenosine (m A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA m A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of...
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| Published in | Trends in cancer |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.07.2022
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| Subjects | |
| Online Access | Get more information |
| ISSN | 2405-8025 |
| DOI | 10.1016/j.trecan.2022.02.010 |
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| Abstract | N
-methyladenosine (m
A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA m
A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of cancers. Targeting FTO holds promising therapeutic significance via suppressing tumor growth, potentiating immunotherapy, and attenuating drug resistance. Here, we review recent advances in our understanding of the functions and underlying molecular mechanisms of FTO in tumor development, cancer stem cell (CSC) self-renewal, microenvironment regulation, immunity, and metabolism and discuss the therapeutic potential of targeting FTO for cancer treatment. |
|---|---|
| AbstractList | N
-methyladenosine (m
A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA m
A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of cancers. Targeting FTO holds promising therapeutic significance via suppressing tumor growth, potentiating immunotherapy, and attenuating drug resistance. Here, we review recent advances in our understanding of the functions and underlying molecular mechanisms of FTO in tumor development, cancer stem cell (CSC) self-renewal, microenvironment regulation, immunity, and metabolism and discuss the therapeutic potential of targeting FTO for cancer treatment. |
| Author | Su, Rui Chen, Jianjun Chen, Yong Deng, Xiaolan Li, Yangchan |
| Author_xml | – sequence: 1 givenname: Yangchan surname: Li fullname: Li, Yangchan organization: Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China – sequence: 2 givenname: Rui surname: Su fullname: Su, Rui email: rsu@coh.org organization: Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. Electronic address: rsu@coh.org – sequence: 3 givenname: Xiaolan surname: Deng fullname: Deng, Xiaolan organization: Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA – sequence: 4 givenname: Yong surname: Chen fullname: Chen, Yong organization: Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China – sequence: 5 givenname: Jianjun surname: Chen fullname: Chen, Jianjun email: jianchen@coh.org organization: Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. Electronic address: jianchen@coh.org |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35346615$$D View this record in MEDLINE/PubMed |
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| Keywords | FTO N-methyladenosine cancer therapeutic target inhibitor immunotherapy |
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-methyladenosine (m
A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first... |
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