FTO in cancer: functions, molecular mechanisms, and therapeutic implications

N -methyladenosine (m A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA m A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of...

Full description

Saved in:
Bibliographic Details
Published inTrends in cancer
Main Authors Li, Yangchan, Su, Rui, Deng, Xiaolan, Chen, Yong, Chen, Jianjun
Format Journal Article
LanguageEnglish
Published United States 01.07.2022
Subjects
FTO
N-methyladenosine
cancer
therapeutic target
inhibitor
immunotherapy
Online AccessGet more information

Cover

More Information
Summary:N -methyladenosine (m A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA m A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of cancers. Targeting FTO holds promising therapeutic significance via suppressing tumor growth, potentiating immunotherapy, and attenuating drug resistance. Here, we review recent advances in our understanding of the functions and underlying molecular mechanisms of FTO in tumor development, cancer stem cell (CSC) self-renewal, microenvironment regulation, immunity, and metabolism and discuss the therapeutic potential of targeting FTO for cancer treatment.
ISSN:2405-8025
DOI:10.1016/j.trecan.2022.02.010