Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment

Graphene quantum dots (GQDs) as novel nanomaterials, have received significant interest in the field of biomedical applications. It is worth noting that a large amount of research is devoted to GQDs-based nanocomposites for cancer treatment, especially for photodynamic therapy (PDT), in that they ca...

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Published inEuropean journal of medicinal chemistry Vol. 182; p. 111620
Main Authors Fan, Hua-yang, Yu, Xiang-hua, Wang, Ke, Yin, Yi-jia, Tang, Ya-jie, Tang, Ya-ling, Liang, Xin-hua
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 15.11.2019
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cancer therapy
Drug Carriers - chemistry
Drug delivery
Graphene quantum dots
Graphite - chemistry
Humans
Nanomaterials
Nanoparticles - chemistry
Neoplasms - drug therapy
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Quantum Dots - chemistry
Structure-Activity Relationship
Nanomaterials
Drug delivery
Photodynamic therapy
Cancer therapy
Graphene quantum dots
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Summary:Graphene quantum dots (GQDs) as novel nanomaterials, have received significant interest in the field of biomedical applications. It is worth noting that a large amount of research is devoted to GQDs-based nanocomposites for cancer treatment, especially for photodynamic therapy (PDT), in that they can act not only as more favorable photosensitizers (PSs) but also nanoplatforms for delivering PSs. In this review, the biological behavior and physicochemical properties of GQDs for PDT are described in detail, and the application of GQDs-based nanocomposites in improved PDT and PDT-based combination therapies is analyzed, which may provide a new strategy for designing efficient PDT systems for cancer treatment. [Display omitted] •The synthesis methods of GQDs have important effects on their physicochemical properties.•GQDs exhibit excellent biocompatibility and optical properties.•GQDs have great potential in photodynamic therapy.•PDT-based combination therapies show good synergistic effects.•Precisely tailoring properties of GQDs plays a key role in their application.
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ISSN:0223-5234
1768-3254
1768-3254
DOI:10.1016/j.ejmech.2019.111620