Improvement in the healing of bone fractures using a cyclodextrin/Ni-MOF nanofibers network: the development of a novel substrate to increase the surface area with desirable functional properties

• Published in: RSC advances Vol. 13; no. 9; pp. 56 - 568
• Main Authors: Lin, Junfei, Zong, Chenyu, Chen, Baisen, Wang, Teng, Xu, Jiacheng, Du, Jiashang, Lin, Yinghao, Gu, Yuming, Zhu, Jianwei
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 14.02.2023; The Royal Society of Chemistry
• Subjects: Biocompatibility; Biodegradability; Chemistry; Controllability; Cyclodextrins; Electrospinning; Flow velocity; Fractures; Healing; Nanofibers; Orthopedics; Regeneration (physiology); Substrates; Surface area; Thermal stability; Tissue engineering
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d2ra05464g

In this study, a β-cyclodextrins (β-CDs)/Ni-based MOF (β-CDs/Ni-based MOF) fibrous network with focus on biocompatible and biodegradable properties was used as a new material for orthopedic applications. The final products were synthesized by an efficient, rapid, and controllable electrospinning route under optimal conditions, including a flow rate of 0.3 mL g −1 , applied voltage of 18 kV, and spinning distance of 20 cm. Efficient characterization by various analyzes showed that the β-CDs/Ni-based MOF fibrous nanostructures had a thermal stability at about 320 °C and homogeneous particles with a narrow size distribution. The BET analysis results showed a specific surface area of 2140 m 2 g −1 for these compounds, which facilized potential conditions needed for the application of these compounds as a new substrate to improve the healing of bone fractures. The results showed the better porosity of the β-CDs/Ni-based MOF scaffolds as an essential property, leading to higher proliferation and nutrition and oxygen delivery, resulting in more tissue regeneration. This study proposes a novel strategy for a fibrous network substrate with distinct properties for orthopedic purposes. In this study, we describe a β-cyclodextrins (β-CDs)/Ni-based MOF (β-CDs/Ni-based MOF) network for orthopedic applications.