A case of Weber-Christian disease with collapsing glomerulopathy

We report a case of Weber-Christian disease confirmed by skin biopsy in a patient who presented with collapsing glomerulopathy and lipophagic interstitial nephritis. On renal biopsy, glomerular visceral epithelial cells, tubular cells, and interstitial macrophages were loaded with inclusions that we...

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Bibliographic Details
Published inAmerican journal of kidney diseases Vol. 48; no. 3; p. 484
Main Authors Nahar, Nilay, Pardo, Victoriano, Sadhu, Sanghamitra, Young, Larry, Gonzalez, Nora, Jaimes, Edgar A
Format Journal Article
LanguageEnglish
Published United States 01.09.2006
Subjects
Adult
Biopsy
Glomerulonephritis - etiology
Glomerulonephritis - pathology
Humans
Male
Panniculitis, Nodular Nonsuppurative - complications
Panniculitis, Nodular Nonsuppurative - pathology
Recurrence
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Summary:We report a case of Weber-Christian disease confirmed by skin biopsy in a patient who presented with collapsing glomerulopathy and lipophagic interstitial nephritis. On renal biopsy, glomerular visceral epithelial cells, tubular cells, and interstitial macrophages were loaded with inclusions that were morphologically consistent with oxidized lipoproteins, suggesting that lipids derived from the panniculitis may have an etiopathogenic role.
ISSN:1523-6838
DOI:10.1053/j.ajkd.2006.05.025