Triggering TLR signaling in vaccination

Toll-like receptors (TLRs) are a family of pattern-recognition receptors that are an important link between innate and adaptive immunity. Many established, as well as experimental, vaccines incorporate ligands for TLRs, not only to protect against infectious diseases but also in therapeutic immuniza...

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Published inTrends in Immunology Vol. 27; no. 1; pp. 49 - 55
Main Authors van Duin, David, Medzhitov, Ruslan, Shaw, Albert C.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 2006
Subjects
Animals
Cell Movement
Dendritic Cells - cytology
Dendritic Cells - immunology
Humans
Immune Tolerance - immunology
Signal Transduction - immunology
Toll-Like Receptors - immunology
Vaccination
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Summary:Toll-like receptors (TLRs) are a family of pattern-recognition receptors that are an important link between innate and adaptive immunity. Many established, as well as experimental, vaccines incorporate ligands for TLRs, not only to protect against infectious diseases but also in therapeutic immunization against noninfectious diseases, such as cancer. We review the underlying mechanisms by which engagement of TLR signaling pathways might trigger an adaptive immune response after immunization. Although the engagement of TLR signaling pathways is a promising mechanism for boosting vaccine responses, questions of efficacy, feasibility and safety remain the subject of active investigation.
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ISSN:1471-4906
1471-4981
1365-2567
DOI:10.1016/j.it.2005.11.005