Synthesis of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-(thiophen-2-yl)dihydroquinolines as potent inhibitors of Mycobacterium tuberculosis

• Published in: European journal of medicinal chemistry Vol. 164; pp. 171 - 178
• Main Authors: Marvadi, Sandeep Kumar, Krishna, Vagolu Siva, Sriram, Dharmarajan, Kantevari, Srinivas
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 15.02.2019; Elsevier
• Subjects: Chemistry, Medicinal; Life Sciences & Biomedicine; Mycobacterium tuberculosis; Pharmacology & Pharmacy; Piperazine; Quinoline; Science & Technology; Thiophene; Vilsmeier-Haack-Arnold reaction; Quinoline; Thiophene; Mycobacterium tuberculosis; Vilsmeier-Haack-Arnold reaction; Piperazine; BEDAQUILINE; DESIGN; AGENTS; FUTURE; ANTITUBERCULAR EVALUATION; DRUG TARGETS
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2018.12.043

A series of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-(thiophen-2-yl)dihydroquinolines 7a–p was designed and synthesized from 2-acetyl thiophene in six step reaction sequence involving modified Bohlmann-Rahtz and Vilsmeier-Haack-Arnold reactions as key transformations. 2-(Thiophen-2-yl)dihydroquinoline was formylated and subsequently chlorinated using DMF-POCl3. The resulting aldehyde was reduced to give an alcohol and then converted to bromide using PBr3. Further coupling of bromide with morpholine, thiomorpholine and N-substituted piperazines resulted in the desired quinolines 7a-p in very good yields. All the new derivatives 7a–p were characterized by their NMR and mass spectral analysis. In vitro screening of new compounds for antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB), resulted in two derivatives 7f and 7p as most potent antitubercular agents (MIC:1.56 μg/mL) with lower cytotoxicity profiles. [Display omitted] •A series of novel 2-thiophenyl dihydroquinoline derivatives were designed and synthesized.•Morpholine, Thiomorpholine and N-substituted piperazines were coupled to quinoline core.•7f &7p showed most potent in vitro antitubercular activity (MIC: 1.56 μg/mL) & low cytotoxicity.