Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review

Breast cancer stands as the primary cause of cancer-related mortality among women worldwide, often presenting with distant metastases upon diagnosis. Ovarian metastases originating from breast cancer represent a range of 3-30% of all ovarian neoplasms. Case Report: Herein, we present the histopathol...

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Published inDiagnostics (Basel) Vol. 14; no. 9; p. 953
Main Authors Faur, Alexandra Corina, Gurban, Camelia Vidiţa, Dăescu, Ecaterina, Tîrziu, Răzvan Vlad, Lazăr, Daniela Cornelia, Ghenciu, Laura Andreea
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.05.2024
Subjects
Breast cancer
Cancer
Carcinoma
Fibromas
Health aspects
Inhibin
Investigations
Keratin
lobular carcinoma
Metastasis
Mortality
Mucins
Ovarian cancer
ovarian metastases
ovarian metastases from non-gynecologic primary sites
Romania
tumor-to-tumor metastases
Tumors
Romania
breast cancer
lobular carcinoma
ovarian metastases from non-gynecologic primary sites
tumor-to-tumor metastases
ovarian metastases
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Summary:Breast cancer stands as the primary cause of cancer-related mortality among women worldwide, often presenting with distant metastases upon diagnosis. Ovarian metastases originating from breast cancer represent a range of 3-30% of all ovarian neoplasms. Case Report: Herein, we present the histopathological, histochemical, and immunohistochemical findings of a rare case involving mucin-producing lobular breast carcinoma metastasizing to an ovarian fibroma in an 82-year-old female previously diagnosed with lobular breast carcinoma. Histopathological examination of the excised tissues revealed a biphasic neoplasm characterized by tumor cells expressing AE-1/AE-3 cytokeratin, mammaglobin, GCDFP-15, inhibin, and calretinin. Positive mucin staining was observed using histochemical techniques, and reticulin fibers were demonstrated using the Gordon-Sweets technique. A final diagnosis of mucin-producing lobular breast carcinoma metastatic to a benign ovarian fibroma was rendered. Conclusion: The occurrence of metastatic breast carcinoma overlaid on an ovarian tumor represents a rare and diagnostically challenging scenario.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14090953