The autotaxin–lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritis

• Published in: European journal of pharmacology Vol. 765; pp. 228 - 233
• Main Authors: Orosa, Beatriz, García, Samuel, Conde, Carmen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.10.2015
• Subjects: Animals; Apoptosis; Arthritis, Experimental - etiology; Arthritis, Experimental - immunology; Arthritis, Experimental - pathology; Arthritis, Rheumatoid - etiology; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Autotaxin; Experimental arthritis; fibroblast like; Humans; ibroblast‐like; Inflammatory response; Lysophosphatidic acid; Lysophospholipids - immunology; Lysophospholipids - metabolism; Phosphoric Diester Hydrolases - immunology; Phosphoric Diester Hydrolases - metabolism; Receptors, Lysophosphatidic Acid - metabolism; Rheumatoid arthritis; Signal Transduction; Synovial Membrane - metabolism; Synovial Membrane - pathology; ibroblast‐like; Lysophosphatidic acid; Experimental arthritis; Autotaxin; Rheumatoid arthritis; Inflammatory response; fibroblast like
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2015.08.028

Lysophosphatidic acid (LPA) is a phospholipid that is mainly produced by the hydrolysis of lysophosphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX). LPA interacts with specific G-protein coupled receptors and is involved in the regulation of cellular survival, proliferation, differentiation and motility. LPA also has roles in several pathological disorders, such as cancer and pulmonary, dermal and renal fibrosis. The involvement of the ATX–LPA pathway has recently been demonstrated in inflammatory responses and apoptosis of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis and during the development of experimental arthritis. This review summarises the current literature of the ATX–LPA pathway in rheumatoid arthritis.