The fight against multidrug-resistant organisms: The role of ZnO crystalline defects

This article reports the excellent antimicrobial response of nanoparticulate ZnO against multidrug-resistant organisms (MDROs). We demonstrate that the enhanced antimicrobial activity against MDROs depends on the crystalline defects of ZnO. Hence, this work provides insights on the ZnO-microorganism...

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Bibliographic Details
Published inMaterials Science & Engineering C Vol. 99; pp. 575 - 581
Main Authors de Lucas-Gil, Eva, Del Campo, Adolfo, Pascual, Laura, Monte-Serrano, Mercedes, Menéndez, Javier, Fernández, José F., Rubio-Marcos, Fernando
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2019
Elsevier BV
Subjects
Action mechanisms
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Antimicrobial properties
Crystal defects
Crystal structure
Crystallinity
Materials science
MDROs
Multidrug resistance
Multidrug resistant organisms
Nanoparticles
Organic chemistry
Zinc oxide
ZnO
Nanoparticles
MDROs
ZnO
Antimicrobial properties
Action mechanisms
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Summary:This article reports the excellent antimicrobial response of nanoparticulate ZnO against multidrug-resistant organisms (MDROs). We demonstrate that the enhanced antimicrobial activity against MDROs depends on the crystalline defects of ZnO. Hence, this work provides insights on the ZnO-microorganism interactions, and we pose combined physico-chemical action mechanisms against resistant bacteria. [Display omitted] •Synthesis of ZnO nanoparticles with antimicrobial response against multidrug-resistant organisms.•A high crystal defect concentration leads to a high surface reactivity and they improve the antibacterial response•Combined action of surface reactivity is mandatory to obtain this inorganic antimicrobial agent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2019.02.004